METHOTREXATE, VIALS 3 Serious Warnings and Precautions Box

methotrexate, vials

(

Serious Warnings and Precautions 

  • Methotrexate Injection USP should be used only by physicians whose knowledge and experience includes the use of antimetabolite therapy because of the possibility of serious toxic reactions (see 7 WARNINGS AND PRECAUTIONS: General). 
  • Methotrexate Injection USP formulations which contain benzyl alcohol are contraindicated in neonates and for intrathecal, intracerebroventricular, or high dose therapy (see 2 CONTRAINDICATIONS).
  • Methotrexate has been reported to cause fetal death and/or congenital anomalies (see 7.1.1 Pregnant Women). Therefore, use is contraindicated for women of childbearing potential until pregnancy is excluded and pregnant patients with psoriasis or rheumatoid arthritis (see 2 CONTRAINDICATIONS).
)

Find METHOTREXATE, VIALS medical information:

Find METHOTREXATE, VIALS medical information:

Our scientific content is evidence-based, scientifically balanced and non-promotional. It undergoes rigorous internal medical review and is updated regularly to reflect new information.

METHOTREXATE, VIALS Quick Finder

Product Monograph
Download Product Monograph

Health Professional Information

3 Serious Warnings and Precautions Box

Serious Warnings and Precautions 

  • Methotrexate Injection USP should be used only by physicians whose knowledge and experience includes the use of antimetabolite therapy because of the possibility of serious toxic reactions (see 7 WARNINGS AND PRECAUTIONS: General). 
  • Methotrexate Injection USP formulations which contain benzyl alcohol are contraindicated in neonates and for intrathecal, intracerebroventricular, or high dose therapy (see 2 CONTRAINDICATIONS).
  • Methotrexate has been reported to cause fetal death and/or congenital anomalies (see 7.1.1 Pregnant Women). Therefore, use is contraindicated for women of childbearing potential until pregnancy is excluded and pregnant patients with psoriasis or rheumatoid arthritis (see 2 CONTRAINDICATIONS).

Resources

Didn’t find what you were looking for? 

Contact us

Call 1-800-463-6001*

*Contact Medical Information. 9AM-5PM ET Monday to Friday; excluding holidays.

Medical Inquiry

Submit a medical question for Pfizer prescription products.

Report Adverse Event

Pfizer Safety

Contact Pfizer Safety to report an adverse event, side effect or concern about the quality of a Pfizer product: 1 866 723-7111.

To report an adverse event related to COMIRNATY, and you are not part of a clinical trial* for this product, click the link below to submit your information:

Pfizer Safety Reporting Site

*If you are involved in a clinical trial for this product, adverse events should be reported to your coordinating study site.

Canada Vigilance Program 

You may also contact the Canada Vigilance Program directly to report adverse events or product quality concerns at 1-866-234-2345 or www.healthcanada.gc.ca/medeffect