METHOTREXATE, VIALS 3 Serious Warnings and Precautions Box

methotrexate, vials

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Serious Warnings and Precautions 

  • Methotrexate Injection USP should be used only by physicians whose knowledge and experience includes the use of antimetabolite therapy because of the possibility of serious toxic reactions (see 7 WARNINGS AND PRECAUTIONS: General). 
  • Methotrexate Injection USP formulations which contain benzyl alcohol are contraindicated in neonates and for intrathecal, intracerebroventricular, or high dose therapy (see 2 CONTRAINDICATIONS).
  • Methotrexate has been reported to cause fetal death and/or congenital anomalies (see 7.1.1 Pregnant Women). Therefore, use is contraindicated for women of childbearing potential until pregnancy is excluded and pregnant patients with psoriasis or rheumatoid arthritis (see 2 CONTRAINDICATIONS).
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3 Serious Warnings and Precautions Box

Serious Warnings and Precautions 

  • Methotrexate Injection USP should be used only by physicians whose knowledge and experience includes the use of antimetabolite therapy because of the possibility of serious toxic reactions (see 7 WARNINGS AND PRECAUTIONS: General). 
  • Methotrexate Injection USP formulations which contain benzyl alcohol are contraindicated in neonates and for intrathecal, intracerebroventricular, or high dose therapy (see 2 CONTRAINDICATIONS).
  • Methotrexate has been reported to cause fetal death and/or congenital anomalies (see 7.1.1 Pregnant Women). Therefore, use is contraindicated for women of childbearing potential until pregnancy is excluded and pregnant patients with psoriasis or rheumatoid arthritis (see 2 CONTRAINDICATIONS).

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