METHOTREXATE, VIALS 3 Serious Warnings and Precautions Box

methotrexate, vials

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Serious Warnings and Precautions

Methotrexate Injection USP should be used only by physicians whose knowledge and experience includes the use of antimetabolite therapy because of the possibility of serious toxic reactions (see 7 WARNINGS AND PRECAUTIONS: General).
Methotrexate Injection USP formulations which contain benzyl alcohol are contraindicated in neonates and for intrathecal, intracerebroventricular, or high dose therapy (see 2 CONTRAINDICATIONS).
Methotrexate has been reported to cause fetal death and/or congenital anomalies (see 7.1.1 Pregnant Women). Therefore, use is contraindicated for women of childbearing potential until pregnancy is excluded and pregnant patients with psoriasis or rheumatoid arthritis (see 2 CONTRAINDICATIONS).

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3 Serious Warnings and Precautions Box

Serious Warnings and Precautions

Methotrexate Injection USP should be used only by physicians whose knowledge and experience includes the use of antimetabolite therapy because of the possibility of serious toxic reactions (see 7 WARNINGS AND PRECAUTIONS: General).
Methotrexate Injection USP formulations which contain benzyl alcohol are contraindicated in neonates and for intrathecal, intracerebroventricular, or high dose therapy (see 2 CONTRAINDICATIONS).
Methotrexate has been reported to cause fetal death and/or congenital anomalies (see 7.1.1 Pregnant Women). Therefore, use is contraindicated for women of childbearing potential until pregnancy is excluded and pregnant patients with psoriasis or rheumatoid arthritis (see 2 CONTRAINDICATIONS).

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