LORBRENA Contraindications

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ACCURETIC is contraindicated in:

  • Patients who are hypersensitive to the drug or to any ingredient in the formulation. For a complete listing, see the Dosage Forms, Composition and Packaging section of the product monograph.
  • Patients with a history of angioedema related to previous treatment with an angiotensin converting enzyme (ACE) inhibitor (see WARNINGS AND PRECAUTIONS, General, Angioedema).
  • Patients hypersensitive to other sulfonamide-derived drugs because of the hydrochlorothiazide component.
  • Patients with anuria.
  • Women who are pregnant, intend to become pregnant, or of childbearing potential who are not using adequate contraception (see WARNINGS AND PRECAUTIONS, Special  Populations, Pregnant Women and ADVERSE REACTIONS).
  • Nursing women (see WARNINGS AND PRECAUTIONS, Special Populations, Nursing Women).
  • Combination with aliskiren-containing medicines in patients with
    • diabetes mellitus (type 1 or type 2),
    • moderate to severe kidney insufficiency (GFR < 60 mL/min/1.73 m2),
    • hyperkalemia (> 5 mMol/L) or
    • congestive heart failure who are hypotensive (see WARNINGS AND PRECAUTIONS, Dual blockade of the Renin-Angiotensin System (RAS) and Renal Impairment, and DRUG INTERACTIONS, Aliskiren-containing medicines and Angiotensin receptor blockers (ARBs) or other ACE inhibitors).
  • Combination with angiotensin receptor blockers (ARBs) or other ACE inhibitors in patients with
    • diabetes with end organ damage,
    • moderate to severe kidney insufficiency (GFR < 60 mL/min/1.73m2),
    • hyperkalemia (> 5mMol/L) or
    • congestive heart failure who are hypotensive (see DRUG INTERACTIONS, Angiotensin receptor blockers (ARBs) or other ACE inhibitors).
  • Patients with hereditary problems of galactose intolerance, glucose-galactose malabsorption or the Lapp lactase deficiency as ACCUPRIL contains lactose (see WARNINGS AND PRECAUTIONS, Sensitivity/Resistance).

 

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Contraindications

ACCURETIC is contraindicated in:

  • Patients who are hypersensitive to the drug or to any ingredient in the formulation. For a complete listing, see the Dosage Forms, Composition and Packaging section of the product monograph.
  • Patients with a history of angioedema related to previous treatment with an angiotensin converting enzyme (ACE) inhibitor (see WARNINGS AND PRECAUTIONS, General, Angioedema).
  • Patients hypersensitive to other sulfonamide-derived drugs because of the hydrochlorothiazide component.
  • Patients with anuria.
  • Women who are pregnant, intend to become pregnant, or of childbearing potential who are not using adequate contraception (see WARNINGS AND PRECAUTIONS, Special  Populations, Pregnant Women and ADVERSE REACTIONS).
  • Nursing women (see WARNINGS AND PRECAUTIONS, Special Populations, Nursing Women).
  • Combination with aliskiren-containing medicines in patients with
    • diabetes mellitus (type 1 or type 2),
    • moderate to severe kidney insufficiency (GFR < 60 mL/min/1.73 m2),
    • hyperkalemia (> 5 mMol/L) or
    • congestive heart failure who are hypotensive (see WARNINGS AND PRECAUTIONS, Dual blockade of the Renin-Angiotensin System (RAS) and Renal Impairment, and DRUG INTERACTIONS, Aliskiren-containing medicines and Angiotensin receptor blockers (ARBs) or other ACE inhibitors).
  • Combination with angiotensin receptor blockers (ARBs) or other ACE inhibitors in patients with
    • diabetes with end organ damage,
    • moderate to severe kidney insufficiency (GFR < 60 mL/min/1.73m2),
    • hyperkalemia (> 5mMol/L) or
    • congestive heart failure who are hypotensive (see DRUG INTERACTIONS, Angiotensin receptor blockers (ARBs) or other ACE inhibitors).
  • Patients with hereditary problems of galactose intolerance, glucose-galactose malabsorption or the Lapp lactase deficiency as ACCUPRIL contains lactose (see WARNINGS AND PRECAUTIONS, Sensitivity/Resistance).

 

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