XALACOM (latanoprost-timolol) Dosage And Administration

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The recommended adult (including the elderly) dosage of XALACOM (latanoprost and timolol maleate) is one drop in the affected eye(s) once daily.  If one dose is missed, treatment should continue with the next dose as normal. 

The use of XALACOM may be considered in patients who require both timolol and latanoprost.  It has not been fully investigated whether patients who are adequately controlled with timolol twice daily plus latanoprost once daily will be effectively controlled with XALACOM once daily.  The IOP lowering effect of XALACOM once daily may be less than that seen with the concomitant administration of timolol twice daily and latanoprost once daily based on the results from a short term clinical trial.  For details of information obtained from the clinical trial, please refer to the CLINICAL TRIALS section.

When using nasolacrimal occlusion or closing the eyelids for 2 minutes, the systemic absorption is reduced. This may result in a decrease in systemic side effects and an increase in local activity.