SOLU-CORTEF (Hydrocortisone sodium succinate for injection USP) Indications And Clinical Use

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  1. Endocrine Disorders

    • In primary, secondary and acute adrenocortical insufficiency (hydrocortisone or cortisone is the drug of choice; synthetic analogs may be used in conjunction with mineralocorticoids where applicable; in infancy, mineralocorticoid supplementation is of particular importance).
    • Congenital adrenal hyperplasia
    • Nonsuppurative thyroiditis
    • Hypercalcemia associated with cancer
  2. Rheumatic Disorders

    As adjunctive therapy for short-term administration (to tide the patient over an acute episode or exacerbation) in:

    • Post-traumatic osteoarthritis
    • Synovitis of osteoarthritis
    • Rheumatoid arthritis, including juvenile rheumatoid arthritis (selected cases may require low-dose maintenance therapy)
    • Acute and subacute bursitis
    • Epicondylitis
    • Acute nonspecific tenosynovitis
    • Acute gouty arthritis
    • Psoriatic arthritis
    • Ankylosing spondylitis
  3. Collagen Diseases

    During an exacerbation or as maintenance therapy in selected cases of:

    • Systemic lupus erythematosus
    • Acute rheumatic carditis
    • Systemic dermatomyositis (polymyositis)
  4. Dermatologic Diseases
    • Pemphigus
    • Severe erythema multiforme (Stevens-Johnson syndrome)
    • Exfoliative dermatitis
    • Bullous dermatitis herpetiformis
    • Severe seborrheic dermatitis
    • Severe psoriasis
    • Mycosis fungoides
  5. Allergic States

    Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment in:

    • Bronchial asthma
    • Contact dermatitis
    • Atopic dermatitis
    • Serum sickness
    • Drug hypersensitivity reactions
    • Urticarial transfusion reactions
  6. Ophthalmic Diseases

    Severe acute and chronic allergic and inflammatory processes involving the eye, such as:
    • Herpes zoster ophthalmicus
    • Iritis, iridocyclitis
    • Chorioretinitis
    • Diffuse posterior uveitis and choroiditis
    • Optic neuritis
    • Sympathetic ophthalmia
    • Anterior segment inflammation
    • Allergic conjunctivitis
    • Allergic corneal marginal ulcers
    • Keratitis
  7. Gastrointestinal Diseases

    To tide the patient over a critical period of the disease in:

    • Ulcerative colitis (systemic therapy)
    • Regional enteritis (systemic therapy)
  8. Respiratory Diseases
    • Symptomatic sarcoidosis
    • Berylliosis
    • Fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy
    • Loeffler's syndrome not manageable by other means
    • Aspiration pneumonitis
  9. Hematologic Disorders
    • Acquired (autoimmune) hemolytic anemia
    • Idiopathic thrombocytopenia purpura in adults (intravenous [I.V.] only; intramuscular [I.M.] administration is contraindicated)
    • Erythroblastopenia (RBC anemia)
    • Congenital (erythroid) hypoplastic anemia
    • Secondary thrombocytopenia in adults
  10. Neoplastic Diseases

    For palliative management of:

    • Leukemias and lymphomas in adults
    • Acute leukemia of childhood
  11. Edematous States

    To induce diuresis or remission of proteinuria in the nephrotic syndrome, without uremia, of the idiopathic type or that due to lupus erythematosus.

  12. Medical Emergencies
    • in the treatment of shock secondary to adrenocortical insufficiency or shock unresponsive to conventional therapy when adrenal cortical insufficiency may be present
    • preoperatively and in the event of serious trauma or illness, in patients with known adrenal insufficiency or when adrenocortical reserve is doubtful
    • in the treatment of acute allergic disorders (status asthmaticus, anaphylactic reactions, insect stings, noninfectious laryngeal edema, etc.) following epinephrine (see WARNINGS AND PRECAUTIONS ).
  13. Miscellaneous

    Tuberculous meningitis with subarachnoid block or impending block when used concurrently with appropriate antituberculous chemotherapy. Trichinosis with neurologic or myocardial involvement.