SODIUM BICARBONATE INJECTION USP (sodium bicarbonate injection USP) Adverse Reactions

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Overly aggressive therapy with Sodium Bicarbonate Injection USP can result in metabolic alkalosis (associated with muscular twitchings, irritability, and tetany) and hypernatremia.

Inadvertent extravasation of intravenously administered hypertonic solutions of sodium bicarbonate have been reported to cause chemical cellulitis because of their alkalinity, with tissue necrosis, ulceration or sloughing at the site of infiltration. Prompt elevation of the part, warmth and local injection of lidocaine or hyaluronidase are recommended to prevent slough­ing of extravasated i.v. infusions.