Keep in a safe place out of the reach of children.
Methotrexate Injection USP (preservative-free) and Methotrexate Injection USP (Pharmacy Bulk Vial, preservative-free): store single-use vials between 15°C and 25°C. Protect from light and freezing. Discard unused portion.
Methotrexate Injection USP (with benzyl alcohol as preservative): store multidose vials between 15°C and 25°C. After the vials are punctured, the vials should be stored between 2°C and 8°C for a maximum of four weeks (30 days). Protect from light and freezing. Aseptic techniques should be used when handling punctured vials to avoid contamination.
It is recommended that the vial remains in the carton until time of use. The Methotrexate Injection USP vial should be inspected for damage and visible signs of leaks. If there are signs of breakage or leakage from the vial, do not use. Incinerate the unopened package.