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INSPRA (eplerenone) Overdosage

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Overdosage

For the management of a suspected drug overdose, contact your regional Poison Control Centre.

In the hypertension clinical trials, increased incidence of hyperkalemia, hyponatremia, hyperglycemia, hypertriglyceridemia, increased GGT, and increased creatinine have been observed with the higher than maximal recommended doses (over 100 mg daily)

No cases of adverse events associated with overdose of INSPRA (eplerenone) in humans have been reported. Lethality was not observed in mice, rats, or dogs after single oral doses that provided Cmax exposures at least 25 times higher than in humans receiving eplerenone 100 mg/day. Dogs showed emesis, salivation, and tremors at a Cmax 41 times the human therapeutic Cmax, progressing to sedation and convulsions at higher exposures.

The most likely manifestation of human overdosage would be anticipated to be hypotension and/or hyperkalemia. Eplerenone cannot be removed by hemodialysis. Eplerenone has been shown to bind extensively to charcoal. If symptomatic hypotension should occur, supportive treatment should be instituted. If hyperkalemia develops, standard treatment should be initiated.

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