FRAGMIN (dalteparin sodium) Drug Interactions

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Drug-Drug Interactions

FRAGMIN should be used with caution in patients receiving oral anticoagulants, platelet inhibitors, non-steroidal anti-inflammatories, thrombolytic agents and dextran because of increased risk of bleeding. Acetylsalicylic acid (ASA), unless contraindicated, is recommended in patients treated for unstable angina or non-Q-wave myocardial infarctions (see DOSAGE AND ADMINISTRATION, ADVERSE REACTIONS).

Because NSAIDs and ASA analgesic/anti-inflammatory doses reduce production of vasodilatatory prostaglandins, and thereby renal blood flow and renal excretion, particular care should be taken when administering dalteparin concomitantly with NSAIDs or high dose ASA in patients with renal failure.

Drug-Food Interactions

Interactions with food have not been established.

Drug-Herb Interactions

Interactions with herbs have not been established.

Drug-Lab tests Interactions

Interactions with lab tests have not been established

Drug-Lifestyle Interactions

Interactions with lifestyle have not been established.