DEPO-PROVERA (medroxyprogesterone acetate injectable suspension, USP) 2 Contraindications

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DEPO-PROVERA (medroxyprogesterone acetate injectable suspension, USP) is contraindicated in women with:

  • Known or suspected pregnancy or as a diagnostic test for pregnancy
  • Undiagnosed vaginal and/or urinary tract bleeding 
  • Known or suspected carcinoma of the breast
  • Undiagnosed breast pathology
  • Known or suspected progestin-dependent neoplasia
  • History of or actual thrombophlebitis or thromboembolic disorders
  • History of or actual cerebrovascular disorders including cerebral apoplexy 
  • History of or actual myocardial infarction or coronary artery disease
  • Presence of severe or multiple risk factor(s) for arterial or venous thrombosis:
    • Severe hypertension (persistent values of ≥160/100 mm Hg)
    • Hereditary or acquired predisposition for venous or arterial thrombosis, such as Factor V Leiden and Prothrombin G20210 A mutation, activated protein C(APC-) resistance, antithrombin-III-deficiency, protein C deficiency, protein S deficiency, hyperhomocysteinaemia and antiphospholipid-antibodies (anticardiolipin antibodies, lupus anticoagulant)
    • Severe dyslipoproteinemia
    • Heavy smoking (>15 cigarettes per day) and over age 35
    • Diabetes mellitus with vascular involvement 
  • Any ocular lesion arising from ophthalmic vascular disease, such as partial or complete loss of vision or defect in visual fields
  • Current or history of migraine with focal aura
  • Active liver disease or history of or actual benign or malignant liver tumours
  • Hypersensitivity to this drug or to any ingredient in the formulation or component of the container.  For a complete listing, see 6 DOSAGE FORMS, STRENGTHS, COMPOSITION AND PACKAGING.

DEPO-PROVERA should not be used before menarche.