DEPO-PROVERA (medroxyprogesterone acetate injectable suspension, USP) is contraindicated in women with:
- Known or suspected pregnancy or as a diagnostic test for pregnancy
- Undiagnosed vaginal and/or urinary tract bleeding
- Known or suspected carcinoma of the breast
- Undiagnosed breast pathology
- Known or suspected progestin-dependent neoplasia
- History of or actual thrombophlebitis or thromboembolic disorders
- History of or actual cerebrovascular disorders including cerebral apoplexy
- History of or actual myocardial infarction or coronary artery disease
- Presence of severe or multiple risk factor(s) for arterial or venous thrombosis:
- Severe hypertension (persistent values of ≥160/100 mm Hg)
- Hereditary or acquired predisposition for venous or arterial thrombosis, such as Factor V Leiden and Prothrombin G20210 A mutation, activated protein C(APC-) resistance, antithrombin-III-deficiency, protein C deficiency, protein S deficiency, hyperhomocysteinaemia and antiphospholipid-antibodies (anticardiolipin antibodies, lupus anticoagulant)
- Severe dyslipoproteinemia
- Heavy smoking (>15 cigarettes per day) and over age 35
- Diabetes mellitus with vascular involvement
- Any ocular lesion arising from ophthalmic vascular disease, such as partial or complete loss of vision or defect in visual fields
- Current or history of migraine with focal aura
- Active liver disease or history of or actual benign or malignant liver tumours
- Hypersensitivity to this drug or to any ingredient in the formulation or component of the container. For a complete listing, see 6 DOSAGE FORMS, STRENGTHS, COMPOSITION AND PACKAGING.
DEPO-PROVERA should not be used before menarche.