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ALESSE (levonorgestrel, ethinyl estradiol) Contraindications


Combination Oral Contraceptives (COCs) are contraindicated in the following:

  • History of or actual thrombophlebitis or thromboembolic disorders.
  • History of or actual cerebrovascular disorders.
  • History of or actual myocardial infarction or coronary arterial disease.
  • Deep vein thrombosis (current or history)
  • Thrombogenic valvulopathies and Thrombogenic rhythm disorders
  • Hereditary or acquired thrombophilias
  • Migraine with focal neurological symptoms such as aura (current or history)
  • Active liver disease or abnormal liver function testing.
  • History of or actual benign or malignant liver tumours.
  • Known or suspected carcinoma of the breast.
  • Known or suspected estrogen-dependent neoplasia.
  • Undiagnosed abnormal vaginal bleeding.
  • Steroid-dependent jaundice, cholestatic jaundice, history of jaundice of pregnancy.
  • Any ocular lesion arising from ophthalmic vascular disease, such as partial or complete loss of vision or defect in visual fields.
  • When pregnancy is suspected or diagnosed.
  • Hypersensitivity to any of the components of ALESSE. For a complete listing, see the DOSAGE FORMS, COMPOSITION AND PACKAGING section of the product monograph.
  • Diabetes with vascular involvement
  • Uncontrolled hypertension
  • Pancreatitis associated with severe hypertriglyceridemia (current or history)
  • Use with the anti-viral Hepatitis C Virus (HCV) combination drug regimen ombitasvir, paritaprevir, ritonavir and dasabuvir, with or without ribavirin (see WARNINGS AND PRECAUTIONS: Hepatic/Biliary/Pancreatic and DRUG INTERACTIONS).

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