ALDACTONE (Spironolactone Tablets, USP) 2 Contraindications

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ALDACTONE is contraindicated in:

  • Patients who are hypersensitive to spironolactone, or to any ingredient in the formulation. For a complete listing, see 6 DOSAGE FORMS, STRENGTHS, COMPOSITION AND PACKAGING.
  • Patients with anuria
  • Patients with Addison’s disease
  • Patients with acute renal insufficiency or with severe impairment of renal function (GFR < 30 mL/Min/1.73 m2
  • Patients with hyperkalemia
  • Women who are pregnant (See 7.1.1 Pregnant Women)
  • Nursing women (see 7.1.2 Breast-feeding)
  • Combination with eplerenone (see 7 WARNINGS AND PRECAUTIONS-, Hematologic, a) Hyperkalemia, and 9 DRUG INTERACTIONS)
  • Combination with heparin, low molecular weight heparin (see 7 WARNINGS AND PRECAUTIONS, Hematologic, Electrolyte Balance, a) Hyperkalemia and 9 DRUG INTERACTIONS)